Is Edaravone the Future of Free Radical Scavenging in Inflammatory States?

Page no. 65 Sir, Free radicals in systemic circulation lead to several forms of diseases involving cardiovascular, cerebrovascular, and respiratory system. They are highly unstable compounds which lead to oxidative damage to cellular lipids, protein, and DNA. A lot of research has been done to investigate the role of free radicals in several diseases.[1] This has led to the development of free radical scavengers. Free radical scavengers that are arbitrarily used in the practice of anesthesiology and critical care are ascorbic acid (Vitamin C), Vitamin E (beta carotene), alpha tocopherol, omega fatty acids, allopurinol, mannitol, multivitamin infusions, selenium.[2] The failure of free radical model could be because it is introduced quite late during management, especially when the damage has occurred. Another reason could be, the dose has not been described by conducting well‐designed studies.